Mitochondrial Fragmentation: The Hidden Driver of Sleep Pressure Uncovered in Flies
A groundbreaking single-cell transcriptomics study reveals that sleep deprivation triggers mitochondrial fragmentation and metabolic stress in specific sleep-control neurons of fruit flies. This fragmentation—accompanied by enhanced mitophagy and altered ER contacts—directly modulates neuronal excitability and sleep drive, suggesting mitochondrial dynamics serve as a fundamental biological timer for sleep homeostasis.